Overview:

EPHB3 is a member of the Ephrin receptor family and is expressed during embryonic development in multiple regions of the central nervous system. In adult brain, EPHB3 is expressed in the cerebellum, raphe pallidus, hippocampus, entorhinal cortex, and both motor and sensory cortices (1). EPHB3 is involved in the maintenance of mature neuronal connections and/or re-arrangement of synaptic connections during late stages of development. EPHB3 plays a role in the regulation of cell adhesion and migration, and the catalytic activity of EPHB3 is required for inhibition of integrin-mediated cell adhesion (2).

Gene Aliases:

ETK2; HEK2; Cek10; Mdk5; TYRO6

Genbank Number:

NM_004443

References:

1. Willson, CA. et al: EphB3 receptor and ligand expression in the adult rat brain. J Mol Histol. 2006 Nov;37(8-9):369-80.

2. Miao, H. et al: Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem. 2005 Jan 14;280(2):923-32.