Recombinant full-length human CDK2/Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C29-19G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C29-19G-05 | 5 ug | $226 | |
| C29-19G-10 | 10 ug | $325 | |
| C29-19G-BULK | BULK | Contact Us |
Overview:
CDK2/CyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity (1). CDK2/CyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle (2).
Gene Aliases:
CDK2: p33 (CDK2) CyclinO: CCNO; CCNU; UDG2
References:
1. Caradonna, S. et.al: Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases. Exp. Cell Res. 222: 345-359, 1996.
2. Muller, S. J. et.al: Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 268: 1310-1319, 1993.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
CDK2 ~58 kDa and Cyclin O ~68 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
C Ianes et al., CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation Amino Acids February 2016 10.1007/s00726-015-2114-y
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
Cancer, Cell Cycle, Ser/Thr Kinases
CDK11, Unactive, C42-14G
CDK2/CyclinE1, Unactive, C29-14G
CDK5P25 Protein, C34-31G
CyclinH1 Protein, C83-30H
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