Overview:

RYK or receptor-like tyrosine kinase is an atypical member of the family of growth factor receptor protein tyrosine kinases. RYK differs from other receptor tyrosine kinases at a number of conserved residues in the activation and nucleotide binding domains (1). RYK has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. RYK is involved in stimulating Wnt signaling pathways such as the regulation of axon path finding (2).

Gene Aliases:

D3S3195; JTK5; JTK5A; RYK1

Genbank Number:

NM_001005861

References:

1. Katso, R. M. et.al: Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. Molec. Cell. Biol. 19: 6427-6440, 1999.

2. Lu, W. et.al: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108, 2004.