Overview:

BUB1 is a kinase which involved in spindle checkpoint function that in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. BUB1 is highly expreesed in thymus, ovary, and testis (1). BUB1 maintains the steady-state level and centromeric localization of SGO1, and they concluded that BUB1 protects centromeric cohesion in mitosis through SGO1 (2). BUB1-mediated phosphorylation of CDC20 is required for proper checkpoint signaling and that inhibition of APC by BUB1 may partly account for the sensitivity of the spindle checkpoint. BUB1 kinase creates a mark for shugoshin localization and the correct partitioning of chromosomes.

Gene Aliases:

BUB1A, BUB1L, hBUB1

Genbank Number:

NM_004336

References:

1. Leland, S.et.al: Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proc. Nat. Acad. Sci. 106: 12776-12781, 2009.

2. Tang, Z.et.al: Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc. Nat. Acad. Sci. 101: 18012-18017, 2004.