Recombinant human TYK2 (JTK1) (442-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T21-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T21-11G-05 | 5 ug | $226 | |
T21-11G-10 | 10 ug | $325 | |
T21-11G-BULK | BULK | Contact Us |
Overview:
TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families which associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. TYK2 play a role in anti-viral immunity and TYK2 plays an indispensable role in controlling responses to multiple cytokines in humans (1). Tyk2 contributes selectively to signals triggered by various biologic stimuli and cytokine receptors and TYK2 is an important regulator of lymphoid tumor surveillance (2).
Gene Aliases:
PSCTK4, MGC126760, MGC126762
Genbank Number:
References:
1. Minegishi, Y. et.al: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25: 745-755, 2006.
2. Stoiber, D. et.al: TYK2 is a key regulator of the surveillance of B lymphoid tumors. J. Clin. Invest. 114: 1650-1658, 2004.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~110 kDa
Product Datasheets
T. Chiveroa Ernest et al., Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function Virology November 2015 10.1016/j.virol.2015.07.008
et al., Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo Journal of Experimental & Clinical Cancer Research : CR March 2021
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway
STAY CONNECTED
Fax: 1-604-232-4601