Overview:

MOS or v-mos Moloney murine sarcoma viral oncogene homolog is a serine/threonine kinase that activate the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (1). The early site-specific phosphorylation of CPEB , which was catalyzed by Eg2 is essential for the polyadenylation of c-mos mRNA, subsequent translation of c-mos, and oocyte maturation (2). The interaction with and phosphorylation of MYOD by MOS enhances muscle differentiation. MOS is an essential component of the cytostatic factor that acts almost exclusively in the second meiotic metaphase arrest.

Gene Aliases:

MGC119962; MGC119963; MSV

Genbank Number:

NM_005372

References:

1. Prasad, C. K. et.al: Mos 3-prime UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. Molec. Reprod. Dev. 75: 1258-1268, 2008.

2. Mendez, R. et.al: Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404: 302-307, 2000.