Recombinant human PLK4 (Full length) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P44-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P44-11G-05 | 5 ug | $226 | |
| P44-11G-10 | 10 ug | $325 | |
| P44-11G-BULK | BULK | Contact Us |
Overview:
PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells (1).The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development (2).
Gene Aliases:
SAK, STK18
Genbank Number:
References:
1. Kleylein-Sohn, J. et.al: Plk4-induced centriole biogenesis in human cells. Dev. Cell 13: 190-202, 2007.
2. Ko, M. A. et.al: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nature Genet. 37: 883-888, 2005.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~140 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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