Overview:

EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses (1). The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2).

Gene Aliases:

GCN2; KIAA1338

Genbank Number:

NM_001013703

References:

1. Berlanga, J. J. et.al: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2-alpha kinase. Europ. J. Biochem. 265: 754-762, 1999.

2. Guo, F. et.al: The GCN2 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5: 103-114, 2007.