Full-length recombinant human ICK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I01-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
I01-10G-05 | 5 ug | $226 | |
I01-10G-10 | 10 ug | $325 | |
I01-10G-BULK | BULK | Contact Us |
Overview:
ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases (1). ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems (2).
Gene Aliases:
ECO; MRK; KIAA0936; LCK2; MGC46090
Genbank Number:
References:
1. Togawa, K. et.al: Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. J. Cell. Physiol. 183: 129-139, 2000.
2. Lahiry, P. et.al: A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~98 kDa
Cell Cycle, ERK/MAPK Pathway, Ser/Thr Kinases
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