Overview:

Cyclin-dependent kinase 10 (CDK10) belongs to cdc2 family of kinases and regulates the cell cycle (1). Cyclin M, the only conventional cyclin partner, protects CDK10 from ubiquitin mediated degradation (2). CDK10/cyclinM positively regulates the degradation of ETS2 through phosphorylation of two neighboring serines. EST2 is a transcription factor that plays key roles in cancer and development. CDK10/CyclinM is also known to repress ciliogenesis and to maintain actin cytoskeletan through the phoshorylation of the PKN2 protein kinase and the control of RhoA stability (3).

Gene Aliases:

CDK10: ALSAS, PISSLRE CyclinM: CCNQ, CycM, FAM58A

Genbank Number:

NM_052988
NM_152274

References:

1. Li, S. et. al: The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res. 55:3992–3995, 1995.

2. Khanal, P. et. al: Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells. Oncogene. 31:3845–56, 2012.

3. Guen, V. J. et. al: The awakening of the CDK10/Cyclin M protein kinase. Oncotarget. 8(30), 50174–50186, 2017.