Overview:

TSSK2 is an intronless serine-threonine kinase that was originally detected on mouse chromosome 16 (1). TSSK2 and TSSK1 share 72% overall amino acid identity and 83% identity in the kinase domain (2). Real-time PCR showed abundant TSSK2 expression in testis and lower levels in heart, brain, and placenta while Western blot analysis detected TSSK2 at the predicted molecular mass of 40kDa in human sperm and testis. Co-immunoprecipitation and yeast 2-hybrid analysis show that TSSK2 can interact with a protein TSKS, that also acts as a substrate for this protein kinase.

Gene Aliases:

DGS-G, SPOGA2, STK22B, FLJ38613

Genbank Number:

NM_053006

References:

1. Nayak, S. et al: Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis. Mech Dev. 1998 Jun;74(1-2):171-4.

2. Hao, Z. et al: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues: a TSSK member is present in the equatorial segment of human sperm. Molec. Hum. Reprod. 10: 433-444, 2004.