Recombinant human InsR (1011-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I08-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
I08-11G-05 | 5 ug | $226 | |
I08-11G-10 | 10 ug | $325 | |
I08-11G-BULK | BULK | Contact Us |
Overview:
InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake (1). Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis (2).
Gene Aliases:
HHF5, CD220
Genbank Number:
References:
1. Okamoto, H. et al: Transgenic rescue of insulin receptor-deficient mice. J. Clin. Invest. 2004;114(2):214-23.
2. Lin, X. et al: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J. Clin. Invest. 2004;114(7):886-8.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70 kDa
Liu J et al., Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor Oncogene September 2013 10.1038/onc.2013.347
Kosten Jonas et al., Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event ACS Chemical Neuroscience October 2014 10.1021/cn5002254
AKT/PKB Pathway, Cancer, Cellular Stress, ERK/MAPK Pathway, Receptor Tyrosine Kinases
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