Recombinant full-length human AURORA A was expressed by baculovirus in Sf9 cells using an N-terminal His(8) tag.
Catalog No. A28-18H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A28-18H-05 | 5 ug | $226 | |
| A28-18H-10 | 10 ug | $325 | |
| A28-18H-BULK | BULK | Contact Us |
Overview:
AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2).
Genbank Number:
References:
1. Dutertre, S. et al: On the role of aurora-A in centrosome function. Oncogene. 2002 Sep 9;21(40):6175-83. 2. Katayama, H. et al: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec;22(4):451-64.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity. For specific information on a given lot, see related technical data sheet.
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Gene Aliases :
AURKA, AIK, ARK1, AURA, AURORA2, BTAK, STK6, STK7, STK15, MGC34538
Storage and Stability:
Store product at –70PoPC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW 50kDa.
There are no related publications available for this product.
Cancer, Cell Cycle
AURORA A, Active, A28-18G
AURORA B, Active, A31-10G
AURORA A, Active, A28-10G
AURORA B, Active, A31-10H
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