The SH2-containing inositol-5′-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.
INPP5D, SHIP, hp51CN, SIP-145, MGC142140, MGC142142
1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.
2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438–445, 1996.
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Inflammation, Lipid Kinases