Overview:

E3 ubiquitin-protein ligase RNF34, also named CARP1 (Caspases-8/10 Associated RING protein 1), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34 is also a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1.

Gene Aliases:

RNF34; CARP; CARP1; hRFI; RFI; RIF; RIFF

Genbank Number:

NM_025126

References:

1. Yang, W. et al: CARPs are E3 ligases that target apical caspases and p53. Cancer Biol. Ther. 6(11):1676-1683, 2007

2. McDonald, E.R. 3rd et al: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. PNAS. 20;101(16):6170-6175, 2004

3. Zhang, R. et al: The E3 Ligase RNF34 is a Novel Negative Regulator of the NOD1 Pathway. Cell Physiol. Biochem. 33:1954-1962, 2014