Overview:

MYC (v-myc myelocytomatosis viral oncogene homolog) is a transcription factor that plays a central role in the regulation of cell growth, proliferation, and metabolism. MYC controls the expression of genes involved in the cell cycle, cell growth, and energy metabolism, and its activity is tightly regulated at multiple levels, including transcriptional and post-transcriptional regulation. MYC is activated by a variety of signaling pathways and is overexpressed in many types of cancer, including lymphoma, leukemia, and solid tumors such as breast and lung cancer. MYC is considered as a major oncogene and its overexpression is associated with poor prognosis and resistance to chemotherapy.

Genbank Number:

P01106-1

References:

1. Kreso, A. & Dick, J.E.: MYC, MAX, and MYCN: oncogenes with distinct functions but not overlapping pathways. Nat. Rev. Cancer. 2018, 18(12): 735-751.