Overview:

PTPRS is a member of a subfamily of receptor type PTPases that is characterized by the presence of an extracellular cell adhesion molecule-like motif and 2 intracellular phosphatase domains (1). The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis (2).

Gene Aliases:

PTP-sigma

Genbank Number:

NM_130855

References:

1. Wagner, J. et al: Olsen, A. S.: Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. Genomics 38: 76-78, 1996.

2. Elchebly, M. et al: Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Nature Genet. 21: 330-333, 1999.