Overview:

DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease (2).

Gene Aliases:

DYRK; PSK47

Genbank Number:

Q63470-2

References:

1. van Bon, B. et al: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly. Clin. Genet. 79: 296-299, 2011.

2. Ryoo, S. R. et al: DYRK1A-mediated hyperphosphorylation of tau: a functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282: 34850-34857, 2007.