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HO1 Protein

Recombinant full-length human HO1 was expressed in E. coli cells using an N-terminal GST tag
Catalog No. H20-30G


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Catalog No. Pack Size Price (USD)
H20-30G-50 50 ug $435
H20-30G-20 20 ug $215
H20-30G-BULK BULK Contact Us  


Overview:

HO1 (Heme oxygenase 1) catalyzes the oxidative cleavage of heme to biliverdin and is one of the main genes controlling heme synthesis and catabolism. HO1 plays a protective role in various disorders and can ameliorate experimental MN via multiple pathways, including anti-oxidative and immunomodulatory effects (1). Exposure of primary hepatocytes to carbon monoxide and nitric oxide results in dramatic induction of HO1 in dose- and time-dependent manner and this induction is blocked by MAP kinase inhibitors (MAPKs) but not by inhibitors of PI3 kinase pathway (2).


Gene Aliases:

HMOX1, HSP32, bK286B10


Genbank Number:


References:


1. Chia-Chao, W.u. et al: HO-1 induction ameliorates experimental murine membranous nephropathy: anti-oxidative, anti-apoptotic and immunomodulatory effects. Nephrology Dialysis Transplantation, 2008; 23(10):3082-3090.

2. Lee, B S. et al: . Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells. Biochem Biophys Res Commun. 2006 May 12;343(3):965-72.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~56 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology


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