Overview:

14-3-3 theta (also known as tyrosine 3-monooxygenase /tryptophan 5-monooxygenase activation protein, theta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Through interaction with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK), 14-3-3 theta plays an important role in controlling apotopsis (1). Induced expression of 14-3-3 theta protein has been reported in patients with amyotrophic lateral sclerosis. Additionally, 14-3-3 theta has been observed to mediate nucleo-cytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) which causes severe acute respiratory syndrome (2).

Gene Aliases:

Ywhaq; 2700028P07Rik; AA409740; AU021156; R74690

Genbank Number:

NM_011739

References:

1. Lau, J.M. et al: The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007, 27(4):1455-66.

2. The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation.J Virol. 2005 Sep;79(17):11476-86.