Home   >    Proteins   >   Signaling Proteins

14-3-3 sigma Protein

Recombinant full-length human 14-3-3 sigma was ex-pressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. Y86-30H

Shop Online

Catalog No. Pack Size Price (USD)
Y86-30H-20 20 ug $314
Y86-30H-50 50 ug $545
Y86-30H-BULK BULK Contact Us  


14-3-3 sigma or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents (1). The induction of 14-3-3 sigma is mediated by a p53 responsive element. Exogenous introduction of 14-3-3 sigma into cycling cells results in a G2 cell cycle arrest (2). Knockout of 14-3-3 sigma in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3sigma -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3sigma-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3 sigma plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death.

Gene Aliases:

14-3-3 sigma, SFN, stratifin, YWHAS

Genbank Number:


1. Chan, T A. et al: 14-3-3-sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620, 1999.

2. Hermeking, H. et al: 14-3-3-sigma is a p53-regulated inhibitor of G2/M progression. Molec. Cell 1: 3-11, 1997.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

30 kDa

Product Datasheets

There are no related publications available for this product.


AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, WNT Signaling


  14-3-3 epsilon Protein, Y75-30H

  14-3-3 sigma Protein, Y86-30G

  14-3-3 zeta Protein, Y92-30BH

  14-3-3 zeta Protein, Y92-30H



Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox