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RGS1 Protein

Recombinant full-length human RGS1 Protein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. R39-30H


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Catalog No. Pack Size Price (USD)
R39-30H-50 50 ug $435
R39-30H-20 20 ug $215
R39-30H-BULK BULK Contact Us  


Overview:

RGS1 is a member of the regulator of G-protein signalling family and attenuates the signalling activity of G-proteins. RGS1 binds to activated GTP-bound G alpha subunit and acts as a GTPase activating protein (GAP) thereby increasing the rate of conversion of GTP to GDP and terminating the signal (1). RGS1 is extensively up-regulated in renal cell carcinoma (RCC) tissues and melanoma. In melanoma, RGS1 expression is significantly correlated with increased tumor thickness, mitotic rate and presence of vascular involvement. Furthermore, there is significant association between increasing RGS1 expression and reduced relapse-free survival as well as disease-specific survival (DSS) survival (2).


Gene Aliases:

IR20, IER1, 1R20, BL34


Genbank Number:


References:


1. Sierra D A, et al: Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002.

2. Rangel J, et al: Novel role for RGS1 in melanoma progression. Am J Surg Pathol. 2008 Aug;32(8):1207-12


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~26 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cell Cycle, ERK/MAPK Pathway, Inflammation, JNK/SAPK Pathway, p38 Pathway, PKA/PKC Pathway



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