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Recombinant human PTPRM (764-1452) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P58-35G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P58-35G-20 | 20 ug | $215 | |
P58-35G-50 | 50 ug | $435 | |
P58-35G-BULK | BULK | Contact Us |
Overview:
PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation (1). PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion (2). PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
Gene Aliases:
RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU
Genbank Number:
References:
1. Phillips-Mason, P.J. et al: The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J. Biol. Chem. 2006; 281(8):4903-10.
2. Koop, E.A. et al: Receptor protein tyrosine phosphatase mu expession as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int. J. Dev. Biol. 2003; 47(5):345-54
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~110 kDa
Cardiovascular Disease, Neurobiology, Phosphatases
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