Methyltransferase Inhibitor
Catalog No. D353-904E
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| D353-904E-5 | 5 mg | $90 | |
| D353-904E-25 | 25 mg | $360 | |
| D353-904E-BULK | BULK | Contact Us |
Overview:
UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 = 45 nM and 2 nM respectively)1. Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells2. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells3.
References:
1. KD Konze et al. ACS Chem. Biol. 2013 8:1324
2. BW Katona et al. Cancer Biol. Ther. 2014 15:1677
3. B Xu et al. Blood 2015 125:346
CAS Registry Number:
1431612-23-5
Molecular Formula:
C33H43N7O2
Appearance:
White powder
Molecular Weight:
569.74
Purity:
>98% (HPLC)
Solubilization:
May be dissolved in DMSO (10 mg/ml)
Aliases:
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
Storage and Stability:
Store desiccated at -20oC. Store solutions at -20oC for 3 months.
Molecular Structure:
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There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology
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