HDAC Inhibitor
Catalog No. H83-904K
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| H83-904K-5 | 5 mg | $120 | |
| H83-904K-25 | 25 mg | $400 | |
| H83-904K-BULK | BULK | Contact Us |
Overview:
Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8)1. Inhibits TNFalpha (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models2. Improves survival in animal models of sepsis3. Improves cognition in Alzheimer's disease transgenic mice4. Cell permeable.
References:
1. KV Butler et al. J. Am. Chem. Soc. 2010 132:10842
2. S Vishwakarma et al. Int. Immunopharmacol. 2013 16:72
3. T Zhao et al. J. Surg. Res. 2014 190:647
4. L Zhang et al. J. Alzheimers Dis. 2014 41:1193
CAS Registry Number:
1239262-52-2
Molecular Formula:
C20H21N3O2·HCl
Appearance:
white powder
Molecular Weight:
371.9
Purity:
99% (HPLC)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride
Storage and Stability:
Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
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