HDAC Inhibitor
Catalog No. H83-904I
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| H83-904I-1 | 1 mg | $105 | |
| H83-904I-05 | 5 mg | $405 | |
| H83-904I-BULK | BULK | Contact Us |
Overview:
A potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively1. Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Recently approved for clinical use in T-cell lymphoma4.
References:
1. R Furumai et al. Cancer Res. 2002 62:4916
2. J Panicker et al. Cell Cycle 2010 9:1830
3. H Ueda et al. J. Antibiot. (Tokyo) 1994 47:315
4. MK VanderMolin et al. J. Antibiot. (Tokyo) 2011 64:525
CAS Registry Number:
128517-07-7
Molecular Formula:
C24H36N4O6S2
Appearance:
Colorless lyophilized wax. (note, vials appear empty)
Molecular Weight:
540.7
Purity:
>98% (HPLC)
Solubilization:
May be dissolved in DMSO (10 mg/ml)
Aliases:
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cell Cycle, Inflammation
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