JMJ H3K27 Demethylase Inhibitor (Cell Perm)
Catalog No. J48-904C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| J48-904C-5 | 5 mg | $110 | |
| J48-904C-25 | 25 mg | $450 | |
| J48-904C-BULK | BULK | Contact Us |
Overview:
Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNFalpha release). Cell permeable, ethyl ester of GSK-J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
References:
1. L Kruidenier et al. Nature 2012 488:404
2. SI Inoue et al. Hum. Mol. Genet. 2014 July 17, Epub
CAS Registry Number:
1373423-53-0
Molecular Formula:
C24H27N5O2
Appearance:
Yellow wax
Molecular Weight:
417.5
Purity:
>99%
Solubilization:
May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)
Aliases:
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Storage and Stability:
Store, as supplied, at -20oC. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cell Cycle, Inflammation
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