JMJ H3K27 Demethylase Inhibitor (Cell Imperm)
Catalog No. J48-904B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| J48-904B-5 | 5 mg | $110 | |
| J48-904B-25 | 25 mg | $450 | |
| J48-904B-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
References:
1. L Kruidenier et al. Nature 2012 488:404
CAS Registry Number:
1373422-53-7
Molecular Formula:
C22H23N5O2
Appearance:
Pale yellow powder
Molecular Weight:
389.5
Purity:
99%
Solubilization:
May be dissolved in DMSO (20 mg/ml, warm)
Aliases:
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
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