Dual HDAC & EGFR Inhibitor
Catalog No. H83-904
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| H83-904-5 | 5 mg | $105 | |
| H83-904-25 | 25 mg | $420 | |
| H83-904-BULK | BULK | Contact Us |
Overview:
A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2, IC50 = 4.4, 2.4 and 15.7 nM respectively1. It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors1,2
References:
1. C.J. Lai et al. Cancer Res. 2010 70:3647
2. X. Cai et al. J. Med. Chem. 2010 53:20
CAS Registry Number:
1012054-59-9
Molecular Formula:
C24H26N4O4
Appearance:
White to off-white powder
Molecular Weight:
434.5
Purity:
>99% (HPLC)
Solubilization:
May be dissolved in DMSO (25 mg/ml)
Aliases:
7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
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