Home   >    Enzymes   >   GTPases & ATPases

VCP, Active

Recombinant full-length human VCP was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. V116-310G


Shop Online



Catalog No. Pack Size Price (USD)
V116-310G-05 5 ug $160
V116-310G-10 10 ug $226
V116-310G-BULK BULK Contact Us  


Overview:

VCP (valosin-containing protein or transitional endo-plasmic reticulum ATPase) is a hexameric ATPase. Like many other members of the AAA (ATPases associated with diverse cellular activities) family, it uses the energy of ATP hydrolysis to structurally remodel client molecules. VCP facilitates the degradation of polyubiquitylated substrates in the proteasome. VCP/p97 has also been linked to various membrane trafficking processes, including Golgi reassembly following mitosis.


Gene Aliases:

ALS14; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA


Genbank Number:


References:


1. Meyer H, et al: The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci. 2014 Sep 15;127(Pt 18):3877-83.

2. Erzberger JP, et al: Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct. 2006;35:93-114.

3. Meyer HH. Golgi reassembly after mitosis: the AAA family meets the ubiquitin family. Biochim Biophys Acta. 2005 Jun 30;1744(2):108-19. Review. Erratum in: Biochim Biophys Acta. 2005 Dec 15;1746(2):169.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

120 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cellular Stress, Inflammation, Neurobiology


RELATED PRODUCTS


  Kinase Dilution Buffer IX, K29-09

  Kinase Assay Buffer III, K03-09

  ATP Stock Solution, A50-09


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox