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RAC2, Active

Recombinant full length human RAC2 was expressed in E.coli cells using an N-terminal His tag.
Catalog No. R104-310H


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Catalog No. Pack Size Price (USD)
R104-310H-05 5 ug $160
R104-310H-10 10 ug $226
R104-310H-BULK BULK Contact Us  


Overview:

RAC2 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins and is involved in a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization and the activation of protein kinases. Knockdown of the gene for both RAC1 and RAC2 completely blocks B-cell development indicating that both GTPases are required to transduce B-cell receptor (BCR) signals leading to proliferation, survival, and the upregulation of BAFF receptor (1). Furthermore, RAC2 is required for the transfer of electrons from NADPH to cytochrome b-associated FAD, then to cytochrome b heme, and finally to oxygen (2).


Gene Aliases:

Gx, EN-7, HSPC022


Genbank Number:


References:


1.Walmsley, M. J. et al: Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302: 459-462, 2003.

2.Diebold, B. A. et al: Molecular basis for Rac2 regulation of phogocyte NADPH oxidase. Nature Immun. 2: 211-215, 2001.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

22 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology



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