NSC-663284
Cdc25 Phosphatase Inhibitor
Catalog No. C04-902
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C04-902-5 | 5 mg | $135 | |
| C04-902-25 | 25 mg | $525 | |
| C04-902-BULK | BULK | Contact Us |
Cdc25 Phosphatase Inhibitor
Catalog No. C04-902
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C04-902-5 | 5 mg | $135 | |
| C04-902-25 | 25 mg | $525 | |
| C04-902-BULK | BULK | Contact Us |
Overview:
Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation2. Inhibits the growth of a variety of human tumor cell lines3. Acts via irreversible oxidation of the catalytic cysteine of CDC254.
References:
1. JS Lazo et al. J. Med. Chem. 2001 44:4042
2. L Pu et al. J. Biol. Chem. 2002 277:46877
3. Y Han et al. J. Pharmacol. Exp. Ther. 2004 309:64
4. M Brisson et al. Mol. Pharmacol. 2005 68:1810
CAS Registry Number:
383907-43-5
Molecular Formula:
C15H16ClN3O3
Appearance:
Red powder
Molecular Weight:
321.8
Purity:
>98%
Solubilization:
May be dissolved in DMSO (15 mg/ml); or ethanol (55 mg/ml)
Aliases:
6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
|
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com