Okadaic acid, free acid
PP2A and PP1 inhibitor
Catalog No. P16-902
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P16-902-20 | 20 ug | $90 | |
| P16-902-100 | 100 ug | $240 | |
| P16-902-BULK | BULK | Contact Us |
PP2A and PP1 inhibitor
Catalog No. P16-902
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P16-902-20 | 20 ug | $90 | |
| P16-902-100 | 100 ug | $240 | |
| P16-902-BULK | BULK | Contact Us |
Overview:
A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation (2). Induces apoptosis in a variety of cell types (3). Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes (4).
References:
1. P Cohen et al. Trends Biochem. Sci.1990 15:98.
2. DG Hardie et al. Methods Ezymol.1991 201:469.
3. TJ Haneji et al. Int. J. Oncol. 2013 42:1904.
4. ML Standaert et al. J. Biol. Chem. 1999 274:14074.
CAS Registry Number:
78111-17-8
Molecular Formula:
C44H68O13
Appearance:
White lyophilized solid
Melting Point:
N/A
Molecular Weight:
805
Purity:
>98% (TLC)
Solubilization:
May be dissolved in DMSO (40 mg/ml); or Ethanol (5 mg/ml)
Aliases:
(6R)-αR,5R-dihydroxy-a,10-dimethyl-8S-[(2E)-1R-methyl-3-[(2R,4'aR,8'aS)-octahydro-8'R-hydroxy-6'S-[1S-hydroxy-3S-[(6S)-3R-methyl-1,7-dioxaspiro[5.5]undec-2S-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5R-yl]-2S-propen-1-yl]-1,7-dioxaspiro[5.5]undec-10-ene-2S-propanoic acid
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20o for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases
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