Overview:

PTPRE or protein tyrosine phosphatase receptor type E is a member of the protein tyrosine phosphatase (PTP) family. This family of proteins are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRE is highly expressed in brain and testis (1). The regulatory roles of this PTP in Ras related signal transduction pathways, cytokines induced signaling, as well as the activation of voltage-gated K+ channels have been identified. PTPRE has a transmembrane segment and a cytoplasmic region containing duplicated PTPase domains (2).

Gene Aliases:

PTPE, P-PTP-epsilon, HPTPE, R-PTP-EPSILON, RP11-380J17.1, DKFZp313F1310, FLJ57799, FLJ58245

Genbank Number:

BC050062

References:

1. Yi, T. et.al: Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood 78: 2222-2228, 1991.

2. Krueger, N. X. et.al: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9: 3241-3252, 1990.