Overview:

The SH2-containing inositol-5′-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.

Gene Aliases:

INPP5D, SHIP, hp51CN, SIP-145, MGC142140, MGC142142

Genbank Number:

NM_005541

References:

1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.

2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438–445, 1996.