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Recombinant full length human PP2Aalpha and human PPP2R1A were expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. P16-20BH
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P16-20BH-05 | 5 ug | $259 | |
| P16-20BH-10 | 10 ug | $380 | |
| P16-20BH-BULK | BULK | Contact Us |
Overview:
PP2Aalpha is also known as Protein phosphatase 2A active subunit. PP2A is one of the four major Ser/Thr phosphatases and is a human tumor suppressor that inhibits cellular transformation. PP2A alpha gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase-2A (1). Protein phosphatase 2A holoenzyme is a heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. PTP2A alpha can alter the substrate specificity of PP2A leading to enhanced phosphotyrosine phosphatase activity and decreased phosphoserine phosphatase activity (2).
Gene Aliases:
PP2Aalpha: RP-C; PP2Ac; PP2CA; PPP2CA
PPP2R1A: MRD36; PP2A-Aalpha; PP2AAALPHA; PR65A
References:
1. Van Hoof, C. et.al: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. Genomics 28: 261-272, 1995.
2. Chao, Y. et.al: Structure and mechanism of the phosphotyrosyl phosphatase activator. Molec. Cell 23: 535-546, 2006.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
PP2Aalpha ~38 kDa and PPP2R1A ~65 kDa
Guisle I et al., Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature Sleep November 2019 10.1093/sleep/zsz266
C Ettelaie et al., Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release. Biochimica et Biophysica Acta November 2016 10.1016/j.bbamcr.2016.09.005
et al., ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II Nature Communications December 2022
et al., Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles. Biochimica et biophysica acta. Molecular cell research April 2018
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