Overview:

TFG-TRKA (TRK-T3) is a chimeric cytoplasmic oncoprotein isolated from a papillary thyroid tumor. This oncoprotein is the consequence of a t(1, 3) translocation juxtaposing the tyrosine kinase domain of the NTRK1 receptor to the N-terminal portion of a protein encoded by TFG (TRK-fused gene), a novel gene first discovered in the rearranged form. TRK-T3 fusion oncoprotein displays a constitutive tyrosine kinase activity resulting in its capability to transform mouse NIH3T3 cells. The TFG portion of TRK-T3 contains a coiled-coil domain most likely responsible for the constitutive, ligand-independent activation of the receptor tyrosine kinase activity through TRK-T3 oligomerization.

Gene Aliases:

TFG: HMSNP; SPG57; TF6
TRKA: NTRK1, MTC, TRK, p140-TrkA

Genbank Number:

NM_001195478
NM_002529

References:

1. Greco A. et al: The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol. 15(11):6118-27, 1995.

2. Greco A, et al. Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene. Oncogene. 12;16(6):809-16, 1998.