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MLCK, Active

Recombinant human MLCK (1425-1776) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. M62-11G


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Catalog No. Pack Size Price (USD)
M62-11G-05 5 ug $226
M62-11G-10 10 ug $325
M62-11G-BULK BULK Contact Us  


Overview:

MLCK or myosin light chain kinase is a muscle member of the immunoglobulin gene superfamily and is a calcium/calmodulin dependent protein kinase. MLCK is a regulatory protein for smooth muscle contraction, which acts by phosphorylating 20-kDa myosin light chain (MLC20) to activate the myosin ATPase activity. The kinase activity for the phosphorylation is localized at the central part of MLCK, which is also furnished with actin-binding activity at its N terminal and myosin-binding activity at its C terminal (1). Phosphorylation of regulatory light chain of myosin plays an important role in controlling the morphological changes seen during cell division (2).


Gene Aliases:

MYLK, KRP, MLCK108, MLCK210, MSTP083, FLJ12216, DKFZp686I10125


Genbank Number:


References:


1. Gao, Y. et al: Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. 2001 Jun;51(6):337-44.

2. Matsumura, F. et al: Role of myosin light chain phosphorylation in the regulation of cytokinesis. Cell Struct Funct. 2001 Dec;26(6):639-44.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Invasion/Metastasis, Ser/Thr Kinases


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