Overview:

FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 (CSF1). FMS is homodimeric that contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. FMS mediates most if not all of the biological effects of CSF1 which control the production, differentiation, and function of cell of the monocyte/macrophage lineage (1). Mutations in FMS have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy (2).

Gene Aliases:

CSF1R, CSFR, FIM2, C-FMS, CD115

Genbank Number:

NM_005211

References:

1. Sherr, C J.: Regulation of mononuclear phagocyte proliferation by colony-stimulating factor-1. Int J Cell Cloning. 1990 Jan;8 Suppl 1:46-60

2. Follows, G A. et al: c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis. Oncogene. 2005 May 19;24(22):3643-51.