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FMS, Active

Recombinant human FMS (539-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C74-11G


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Catalog No. Pack Size Price (USD)
C74-11G-05 5 ug $226
C74-11G-10 10 ug $325
C74-11G-BULK BULK Contact Us  


Overview:

FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 (CSF1). FMS is homodimeric that contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. FMS mediates most if not all of the biological effects of CSF1 which control the production, differentiation, and function of cell of the monocyte/macrophage lineage (1). Mutations in FMS have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy (2).


Gene Aliases:

CSF1R, CSFR, FIM2, C-FMS, CD115


Genbank Number:


References:


1. Sherr, C J.: Regulation of mononuclear phagocyte proliferation by colony-stimulating factor-1. Int J Cell Cloning. 1990 Jan;8 Suppl 1:46-60

2. Follows, G A. et al: c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis. Oncogene. 2005 May 19;24(22):3643-51.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~76 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Metabolic Disorder


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