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EPHB1, Active

Recombinant mouse EPHB1 (591-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. E21-11G


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Catalog No. Pack Size Price (USD)
E21-11G-05 5 ug $226
E21-11G-10 10 ug $325
E21-11G-BULK BULK Contact Us  


Overview:

EPHB1 is a member of the Eph family of receptor tyrosine kinases. Ligand-activated EPHB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration (1). In addition, activated EPHB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation. Expression of dominant-negative c-Src significantly reduced EPHB1-dependent ERK1/2 activation and chemotaxis (2).


Gene Aliases:

Elk, Net, Cek6, Elkh, Hek6, EPHT2, AW488255, 9330129L11


Genbank Number:


References:


1. Vindis, C. et al: EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem. 2004 Jul 2;279(27):27965-70.

2. Vindis, C. et al: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003 Aug 18;162(4):661-71.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases


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