Home   >    Proteins   >   Protein Kinases

BTK, Active

Recombinant full-length human BTK was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.
Catalog No. B10-10H


Shop Online



Catalog No. Pack Size Price (USD)
B10-10H-05 5 ug $226
B10-10H-10 10 ug $325
B10-10H-BULK BULK Contact Us  


Overview:

BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1). Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2).


Gene Aliases:

AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK


Genbank Number:


References:


1. Cheng, G. et al: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Nat. Acad. Sci. 91: 8152-8155, 1994.

2. Vassilev, A O. et al: Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK). Curr Pharm Des. 2004;10(15):1757-66.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~78 kDa



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway


RELATED PRODUCTS


  ITK, Active, I13-11G

  LCK, Active, L03-10G

  ZAP70, Active, Z02-10G

  BTK (R562P) Protein, B10-12DH


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox