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MST4, Active

Recombinant full-length human MST4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M59-10G


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Catalog No. Pack Size Price (USD)
M59-10G-05 5 ug $226
M59-10G-10 10 ug $325
M59-10G-BULK BULK Contact Us  


Overview:

MST4 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20), and have a role in mitogen-activated protein kinase signaling during cytoskeletal rearrangement, morphogenesis, apoptosis, and other diverse cellular events (1). Expression of MST4 has been shown to correlate with tumorigenicity and inversely with androgen receptor status in a number of human prostate cancer cell lines. Overexpression of MST4 induced anchorage-independent growth and increased in vitro proliferation of these prostate cancer cell lines (2).


Gene Aliases:

MASK; RP6-213H19.1; STK26


Genbank Number:


References:


1. Dan, I. Et al: Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J. Biol. Chem. 277: 5929-5939, 2002.

2. Sung, V. et al: The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res. 63: 3356-3363, 2003.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~72kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, Neurobiology, Receptor Tyrosine Kinases


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