TRIB2 or tribbles homolog 2 proteins encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB2 protein interacts and modulates the activity of signal transduction pathways in a number of physiological and pathological processes. TRIB2 is regulated by inflammatory stimuli in myeloid (THP-1) cells. TRIB2 can act as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia (1). TRIB2 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2).
1. Wilkin, F. et.al: Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Europ. J. Biochem. 248: 660-668, 1997.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
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