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TRIB2 Protein

Recombinant full-length human TRIB2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T31-30G


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Catalog No. Pack Size Price (USD)
T31-30G-20 20 ug $215
T31-30G-50 50 ug $435
T31-30G-BULK BULK Contact Us  


Overview:

TRIB2 or tribbles homolog 2 proteins encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB2 protein interacts and modulates the activity of signal transduction pathways in a number of physiological and pathological processes. TRIB2 is regulated by inflammatory stimuli in myeloid (THP-1) cells. TRIB2 can act as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia (1). TRIB2 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2).


Gene Aliases:

GS3955, TRB2


Genbank Number:


References:


1. Wilkin, F. et.al: Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Europ. J. Biochem. 248: 660-668, 1997.

2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~64 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Metabolic Disorder


RELATED PRODUCTS


  TRIB1 Protein, T30-30G

  TRIB3 Protein, T32-30G


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