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KSR2, Active

Recombinant human KSR2 (554-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K08-11G


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Catalog No. Pack Size Price (USD)
K08-11G-05 5 ug $226
K08-11G-10 10 ug $325
K08-11G-BULK BULK Contact Us  


Overview:

KSR2 or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family (1). KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans (2).


Gene Aliases:

none


Genbank Number:


References:


1. Brennan, D. F.et.al: A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 472: 366-369, 2011.

2. Channavajhala, P. L.et.al: hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappa-B pathways in inflammation. Biochem. Biophys. Res. Commun. 334: 1214-1218, 2005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~72 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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