Recombinant human PIP5K3 (1493-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P17-31G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P17-31G-20 | 20 ug | $215 | |
P17-31G-50 | 50 ug | $435 | |
P17-31G-BULK | BULK | Contact Us |
Overview:
PIP5K3 (also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) encodes an enzyme that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol but also have protein kinase activity (1). PIP5K3 regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. The inhibition of PIP5K3 renders the late endosome/lysosome compartment refractory to fusion with autophagosomes and multivesicular bodies (2).
Gene Aliases:
PIKFYVE; CFD; FAB1; PIP5K; FLJ37746; KIAA0981; MGC40423
Genbank Number:
References:
1. Shisheva, A..et.al: Cloning, characterization, and expression of a novel Zn(2+)-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Molec. Cell. Biol. 19: 623-634, 1999.
2. de Lartigue, J.et.al: PIKfyve regulation of endosome-linked pathways. Traffic 10: 883-893, 2009.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~ 93 kDa
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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