Recombinant human BCKDK (30-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B15-31G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B15-31G-20 | 20 ug | $215 | |
B15-31G-50 | 50 ug | $435 | |
B15-31G-BULK | BULK | Contact Us |
Overview:
BCKDK or branched chain alpha-keto acid dehydrogenase kinase is an important regulator of the valine, leucine, and isoleucine catabolic pathways. BCKDK is found in the mitochondrion where it phosphorylates and inactivates BCKD. The branched-chain alpha-keto dehydrogenase complex (BCKDH) catalyzes the rate-limiting step in the oxidation of branched-chain amino acids and BCKDK inactivates the BCKDH complex by catalyzing serine phosphorylation of the E1-alpha subunit (1). BCKDH kinase catalyzes the serine phosphorylation of the E1- alpha subunit of BCKDH (2).
Gene Aliases:
BCKDKD; BDK
Genbank Number:
References:
1. Joshi, M. A. et.al: growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. Biochem. J. 400: 153-162, 2006.
2. Popov, K. M. et.al: A. Branched-chain alpha-ketoacid dehydrogenase kinase: molecular cloning, expression, and sequence similarity with histidine protein kinases. J. Biol. Chem. 267: 13127-13130, 1992.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –700C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~69 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Metabolic Disorder, Neurobiology, Ser/Thr Kinases
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