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p38 delta, Unactive

Recombinant full-length human p38delta was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. M38-14G


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Catalog No. Pack Size Price (USD)
M38-14G-20 20 ug $215
M38-14G-50 50 ug $435
M38-14G-BULK BULK Contact Us  


Overview:

p38δ (SAPK4) is a member of the p38 MAPK family and is activated by chemical and environmental stresses as well as by proinflammatory cytokines. P38δ has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).


Gene Aliases:

SAPK4; PRKM13; MAPK13


Genbank Number:


References:


1. Goedert, M. et al: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16: 3563-3571, 1997.

2. Kumar, S. et al: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~65 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  p38 alpha, Unactive, M39-14G

  p38 gamma, Unactive, M37-14G

  p38 gamma, Active, M37-10BG

  p38 delta, Active, M38-10BG


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