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IKK beta, Active

Recombinant human IKKβ (1-662) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I03-10BG


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Catalog No. Pack Size Price (USD)
I03-10BG-05 5 ug $226
I03-10BG-10 10 ug $325
I03-10BG-BULK BULK Contact Us  


Overview:

IKKβ is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKβ is stimulated by TNF and IL1 and IKKβ forms a heterodimer that interacts with NIK (1). Overexpression of catalytically inactive IKKβ blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKKβ activity in vitro and in vivo by binding to IKKβ to reduce ATP binding (2).


Gene Aliases:

IKK2, IKBKB, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801


Genbank Number:


References:


1. Woronicz, J D. et al: IkappaB kinase-beta: NF-kappa-B activation and complex formation with IkappaB kinase-alpha and NIK. Science 278: 866-869, 1997.

2. Yin, M.-J. et al: The anti-inflammatory agents aspirin and salicylate inhibit the activity of I-kappa-B kinase-beta. Nature 396: 77-80, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~105 kDa



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway


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