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GRK3, Active

Recombinant human GRK3 (1-554) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A15-11G

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Catalog No. Pack Size Price (USD)
A15-11G-05 5 ug $226
A15-11G-10 10 ug $325
A15-11G-BULK BULK Contact Us  


GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function (1). GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue (2). Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder.

Gene Aliases:


Genbank Number:


1. Benovic, J. L. et.al: Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2: a new member of the receptor kinase family. J. Biol. Chem. 266: 14939-14946, 1991.

2. Parruti, G. et.al: Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. Biochem. Biophys. Res. Commun. 190: 475-481, 1993.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~84 kDa

Product Datasheets

There are no related publications available for this product.


Angiogenesis, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Metabolic Disorder, Neurobiology, Ser/Thr Kinases


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