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NEK5, Active

Recombinant human NEK5 (1-508) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N07-11G


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Catalog No. Pack Size Price (USD)
N07-11G-05 5 ug $226
N07-11G-10 10 ug $325
N07-11G-BULK BULK Contact Us  


Overview:

NEK5 or NIMA (never in mitosis gene a)-related kinase 5 is a serine/threonine kinase that is involved in cell cycle regulation. NEK5 has been shown to interact with NEK6 and NEK5 are required for the ibo1/nek6 ectopic outgrowth phenotype in epidermal cells (1). NEK6 interacts and co-localizes with NEK5 in a transient expression assay. The ibo1-3 mutation markedly increases the interaction between NEK6 and NEK5. NEK6 forms heterodimers with NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of β-tubulins. The NEK5 gene is conserved in chimpanzee, cow, mouse, rat, and chicken.


Gene Aliases:

MGC75495


Genbank Number:


References:


1. Motose, H. et al: NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana. Plant J. 2011 Sep;67(6):993-1005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~84 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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